Etizolam produces a relaxing and mellowing high as a central nervous system depressant drug. In higher doses, it can have hypnotic and euphoric effects.
An etizolam high can also cause a host of uncomfortable side effects like nausea, dizziness, lethargy, memory loss, and loss of consciousness. Since etizolam is not regulated in the United States, it is tough to know what is contained in the drug you are taking and how the dosage may impact you. It can be difficult to get the dosage just right.
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Regular use of etizolam can be habit-forming and may lead to addiction. An etizolam high is not worth the possible short and long-term risks.
What Is Etizolam?
Etizolam is a thienodiazepine, a similar drug class to benzodiazepines, which are sedatives and hypnotic medications used to treat anxiety and panic disorders as well as enhance relaxation and sleep. It is considered a benzodiazepine analog.
While it is used in other countries as a prescription medication, the U.S. Drug Enforcement Administration (DEA) states that etizolam has no accepted medicinal uses in the United States. This means that any use of etizolam in America is considered illegal and recreational.
While etizolam is considered a benzodiazepine-like drug, it is more than 10 times more potent than Valium (diazepam). It can have sedative and hypnotic effects in much lower doses than traditional benzos.
It is used in Japan, Italy, and India as a medication to manage generalized anxiety disorder and improve depressive symptoms. Since it is not controlled in the U.S., it does not have any legal or accepted medical uses. It is often marketed as a “research chemical.”
As a central nervous system depressant, etizolam reduces blood pressure and slows heart rate while calming the system and lowering body temperature. It interacts with chemicals in the brain that causes relaxation and sedation.
Etizolam works fast and has a relatively short half-life of around three hours. This means that the drug also wears off faster than many other sedative/hypnotics. Xanax (alprazolam) has a half-life averaging near 11 hours, for example.
The quick action and short duration of etizolam can make it appealing to take more of the drug or dose more often, which can be hazardous.
The Etizolam High
In low doses, etizolam works as a muscle relaxant, sedative, and anxiety-reducing medication. It may act similar to alcohol, causing a mellowing buzz, and it may also impair reflexes, thinking, memory, and motor control.
The etizolam high depends on the dose. Lower doses can feel similar to being drunk, with lowered inhibitions, heightened socialization, and general good feelings. The buzz can feel pleasant and relaxing.
Higher doses of etizolam can make you feel like you are sober when you aren’t and cause emotional numbness.
While you won’t feel anxiety, you also may not feel much of anything at all. Many people report not even being able to get high from etizolam like they can with other benzodiazepines.
Everyone will react to the drug differently. Because it’s not controlled or regulated in the United States, it can be harder to predict what your reaction might be.
Since you have to buy it illicitly, often from questionable sources, the etizolam you are taking can contain other toxins, drugs, chemicals, or have variable dosage levels.
An etizolam high can be unpredictable, and it may not even have the desired effects.
Possible Side Effects
Just like benzodiazepine drugs, etizolam can produce the following physical side effects:
- Muscle weakness
- Slurred speech
- Lack of motor coordination
- Loss of consciousness
Etizolam can also make you feel like you are extremely sleep deprived. The high can sometimes cause you to feel like you are going to pass out and like you haven’t slept in days. It can also cause blepharospasm (involuntary closing of the eyes). You can overdose on etizolam as well, which can be fatal.
In addition to physical side effects, etizolam interacts with the brain and emotions. It can cause you to behave in ways you wouldn’t normally. An etizolam high can cause the following:
- Aggression and hostility
- Memory loss
- Increased risk-taking behaviors
- Inflated ego
- Increased sex drive, which may lead to unsafe sexual encounters
- Elevated appetite
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Risk for Addiction
Benzos are considered highly addictive, partly due to the level of physical dependence that can occur with regular use. When you try to stop taking a benzodiazepine, the side effects can be both physically and emotionally difficult and potentially dangerous.
The World Health Organization (WHO) relays that etizolam may cause similar levels of dependence and withdrawal symptoms with repeated use. Withdrawal can include the following:
- Sleep disturbances
- Heart palpitations
The fast action of etizolam and how quickly it wears off can lead to increased anxiety after the drug processes out of the body, which can also raise the risk of dependence and addiction.
The etizolam high can have lasting side effects, which can include struggling with compulsive drug use and an inability to control how much and how often you take it — in other words, addiction. The high is just not worth the risks.
(October 2018) Etizolam. Drug Enforcement Administration (DEA). Retrieved May 2019 from from https://www.deadiversion.usdoj.gov/drug_chem_info/etizolam.pdf
(June 2011) Xanax. Pfizer. Retrieved May 2019 from from https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/018276s045lbl.pdf
(November 2015) Etizolam (INN) Pre-Review Report. World Health Organization (WHO). Retrieved May 2019 from from https://www.who.int/medicines/access/controlled-substances/5.7_Etizolam_PreRev.pdf
(November 2017) Etizolam Critical Review Report. World Health Organization (WHO). Retrieved May 2019 from from https://www.who.int/medicines/access/controlled-substances/CriticalReview_Etizolam.pdf?ua=1
(November-December 2014) A Case of Etizolam Dependence. Indian Journal of Pharmacology. Retrieved May 2019 from from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264086/